The astonishing true story of how Catherine the Great joined forces with a Quaker doctor from Essex to spearhead one of the first global public health campaigns.

‘It is hard to imagine a more timely or important book… a must-read’ Jojo Moyes

‘A rich and wonderfully urgent work of history’ Tristram Hunt

A killer virus…an all-powerful Empress…an encounter cloaked in secrecy…the astonishing true story.

Within living memory, smallpox was a dreaded disease. Over human history it has killed untold millions. Back in the eighteenth century, as epidemics swept Europe, the first rumours emerged of an effective treatment: a mysterious method called inoculation.

But a key problem remained: convincing people to accept the preventative remedy, the forerunner of vaccination. Arguments raged over risks and benefits, and public resistance ran high. As smallpox ravaged her empire and threatened her court, Catherine the Great took the momentous decision to summon the Quaker physician Thomas Dimsdale to St Petersburg to carry out a secret mission that would transform both their lives. Lucy Ward expertly unveils the extraordinary story of Enlightenment ideals, female leadership and the fight to promote science over superstition.

‘A truly fascinating book that reads like a thriller’ Venki Ramakrishnan